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The Xenofish platform provides its expertise in the use of zebrafish through a range of specialized services from micro-injection to support for innovative projects.

Use of the zebrafish (Danio rerio) model

The zebrafish (Danio rerio), a transparent in vivo model, offers rapid growth and strong genetic similarity to humans, allowing for real-time study of biological and pathological processes in the embryo and adult.

Use of the zebrafish (Danio rerio) model

Micro-injection

Microinjection of tumor cells into zebrafish embryos allows for real-time modeling of tumor progression and cell-microenvironment interactions, and for the development of innovative targeted therapies.

Tumor modeling

Angiogenesis in vivo

The Tg(fli1:EGFP) transgenic cell line enables the in vivo study of angiogenesis. It facilitates the analysis of the mechanisms involved in vascular diseases and cancer, as well as the screening of molecules and the analysis of new treatments targeting vascularization.

Studies of angiogenesis and hematopoiesis

Molecule screening

Zebrafish larvae are widely used for screening molecules, allowing in vivo evaluation of the therapeutic efficacy and toxicity of compounds on embryos and adults, while facilitating the development of new molecules targeting various pathologies.

Molecule screening

CRISPR/Cas9, Morpholinos

Creation of transgenic lines of interest using technologies such as morpholinos or CRISPR/Cas9 by micro-injecting 1 cell into the zebrafish embryo.

Modification of a gene sequence

Tissue regeneration

Tissue regeneration tests in zebrafish allow the study of cellular and molecular mechanisms of tissue reconstruction and the identification of potential therapeutic strategies.

Tissue regeneration

Project support

Personalized support for the scientific project at each experimental stage, from design to analysis.

Project support

Monitoring of Imaging Results

The Xenofish platform ensures precise monitoring of results thanks to high-resolution imaging. The data allows for real-time observation of the effects of treatments and the evolution of pathologies.

Monitoring of Imaging Results

Biological Resources

  • Access to different zebrafish lines

  • Production of wild and transgenic eggs and embryos and breeding adapted to the needs of the projects

Equipment

  • 2 Femtojet 4i micromanipulation stations

  • 1 micromanipulation station equipped with a MOTICAM 1080N color screen camera station

  • 1 KOFP Model 720 capillary stretcher

  • 1 Epifluorescence and Transmission Echo Microscope

  • 1 Nikon Eclipse TS100 microscope

Services

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