
The Xenofish platform provides its expertise in the use of zebrafish through a range of specialized services from micro-injection to support for innovative projects.
Use of the zebrafish (Danio rerio) model
The zebrafish (Danio rerio), a transparent in vivo model, offers rapid growth and strong genetic similarity to humans, allowing for real-time study of biological and pathological processes in the embryo and adult.

Micro-injection
Microinjection of tumor cells into zebrafish embryos allows for real-time modeling of tumor progression and cell-microenvironment interactions, and for the development of innovative targeted therapies.

Angiogenesis in vivo
The Tg(fli1:EGFP) transgenic cell line enables the in vivo study of angiogenesis. It facilitates the analysis of the mechanisms involved in vascular diseases and cancer, as well as the screening of molecules and the analysis of new treatments targeting vascularization.

Molecule screening
Zebrafish larvae are widely used for screening molecules, allowing in vivo evaluation of the therapeutic efficacy and toxicity of compounds on embryos and adults, while facilitating the development of new molecules targeting various pathologies.

CRISPR/Cas9, Morpholinos
Creation of transgenic lines of interest using technologies such as morpholinos or CRISPR/Cas9 by micro-injecting 1 cell into the zebrafish embryo.

Tissue regeneration
Tissue regeneration tests in zebrafish allow the study of cellular and molecular mechanisms of tissue reconstruction and the identification of potential therapeutic strategies.

Project support
Personalized support for the scientific project at each experimental stage, from design to analysis.

Biological Resources
Access to different zebrafish lines
Production of wild and transgenic eggs and embryos and breeding adapted to the needs of the projects
Equipment
2 Femtojet 4i micromanipulation stations
1 micromanipulation station equipped with a MOTICAM 1080N color screen camera station
1 KOFP Model 720 capillary stretcher
1 Epifluorescence and Transmission Echo Microscope
1 Nikon Eclipse TS100 microscope

